USMLE Forum Archives - USMLE Step 1 - 19
19
drspleen - 03-14-11 23:58
A 42-year-old male presents for a routine annual clinic visit. He is known to have a mutation of a tumor suppressor on chromosome 17. Examination shows dozens of light-brown macules and scoliosis. Both are unchanged compared to the previous year. Which tumor is this patient at increased risk of developing?
* A. Leukemia
* B. Wilms tumor
* C. Optic glioma
* D. Rhabdomyosarcoma
* E. All of the above
drspleen - 03-14-11 23:58
A 42-year-old male presents for a routine annual clinic visit. He is known to have a mutation of a tumor suppressor on chromosome 17. Examination shows dozens of light-brown macules and scoliosis. Both are unchanged compared to the previous year. Which tumor is this patient at increased risk of developing?
* A. Leukemia
* B. Wilms tumor
* C. Optic glioma
* D. Rhabdomyosarcoma
* E. All of the above
The correct answer and explanation will be available after you answer.
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#1
Re: 19 babbu5508 - 03-19-11 14:21 My answer is: e.
People who inherit only one functional copy of the TP53 gene will most likely develop tumors in early adulthood, a disease known as Li-Fraumeni syndrome.
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