USMLE Forum Archives - USMLE Step 1 - 3745
3745
babbu5508 - 02-26-11 15:46
A 60-year-old man presents to his physician after a routine screening test indicates hyperlipidemia. Physical examination reveals raised, irregular, yellow papules in the skin of the soft tissues below the eyes. Biopsy of these lesions would most likely show which of the following?
Options:
A. Benign nevus cells
B. Malignant nevus cells
C. Microscopic blisters
D. Munro microabscesses
E. Multinucleated giant cells
babbu5508 - 02-26-11 15:46
A 60-year-old man presents to his physician after a routine screening test indicates hyperlipidemia. Physical examination reveals raised, irregular, yellow papules in the skin of the soft tissues below the eyes. Biopsy of these lesions would most likely show which of the following?
Options:
A. Benign nevus cells
B. Malignant nevus cells
C. Microscopic blisters
D. Munro microabscesses
E. Multinucleated giant cells
The correct answer and explanation will be available after you answer.
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#2
Re: 3745
babbu5508 - 02-27-11 03:35 The correct answer is E. The lesions are xanthomas, which are tumor-like dermal collections of foamy histiocytes containing cholesterol and lipids. The lesions may also contain multinucleated giant cells (Touton giant cells) with clustered nuclei and foamy cytoplasm.
#7
Re: 3745 sudha2015 - 03-15-11 11:23 A 60-year-old man presents to his physician after a routine screening test indicates hyperlipidemia. Physical examination reveals raised, irregular, yellow papules in the skin of the soft tissues below the eyes. Biopsy of these lesions would most likely show which of the following
e
#8
Re: 3745 babbu5508 - 03-16-11 16:22 right answer..just in case to let you know because you didnt use the mcq feature...you might not be knowing the answer..
#13
Re: 3745 babbu5508 - 03-18-11 20:40 Xanthomas may be idiopathic or may be related to hyperlipidemia or lymphoproliferative malignancies (e.g., leukemias and lymphomas).
#16
Re: 3745 babbu5508 - 03-19-11 12:18 
posted by drspleen on 03-19-11 02:12
E. Xanthoma in myeloproliferative disorders ? mechanism
E. Xanthoma in myeloproliferative disorders ? mechanism
The triple association of leukemia, xanthomatous skin lesions, and neurofibromatosis 1 (NF) was described but the exact mechanism is not known
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