USMLE Forum Archives - USMLE Step 1 - amyloidosis
amyloidosis
agamamber - 02-25-08 11:34
A 47 old construction is diagnosed with myeloma associated amyloidosis .which of the following is least likely to be affected?
1 heart
2kidney
3peripheral nervous sys
4skin
tongue
agamamber - 02-25-08 11:34
A 47 old construction is diagnosed with myeloma associated amyloidosis .which of the following is least likely to be affected?
1 heart
2kidney
3peripheral nervous sys
4skin
tongue
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#2
Re: amyloidosis matilda - 02-25-08 12:17 All .
Amyloid is a fibrillary protein which deposits in intersticial tissues resulting in the organ disfunction.Amyloid is derived from different proteins.
Common sites of involvments are:
Heart (restrictive cardiomyopathy)
Spleen
Tongue
Adrenals
Liver
Kidneys
Musculoskeletal(Carpal tunel Synd )
CNS (Alzheimer beta amyloid,Anyloid is toxis to neurons.
Medullary carcinoma of thyroid
#5
Re: amyloidosis matilda - 02-25-08 12:47 
posted by agamamber on 02-25-08 12:37
U HAVE TO GIVE ONE CHOICE.
U HAVE TO GIVE ONE CHOICE.
hmmm
Maybe choice 3 ?
#7
Re: amyloidosis
agamamber - 02-25-08 13:38 ans. is kidney.it is imp to know that renal involvement in multiple myeloma /primary amyloidosis is actually less than other struc.
#8
Re: amyloidosis matilda - 02-25-08 14:19 posted by agamamber on 02-25-08 13:38
ans. is kidney.it is imp to know that renal involvement in multiple myeloma /primary amyloidosis is actually less than other struc.
ans. is kidney.it is imp to know that renal involvement in multiple myeloma /primary amyloidosis is actually less than other struc.
What book are you reading please ? Does this fact comes from a very recent Journal.
Please let me know
Thank you
#9
Re: amyloidosis sshahraz - 02-25-08 17:19 This is a tricky question and I don't think usmle asks about the leasts vs. most common. I am saying this is tricky because I suspect there is any evidence out there supporting the percentage of types of renal involvement in MM. I mean if kidneys primarily affected or not. But according to UpToDate you can see that in general kidney involvement is not uncommon:
"Renal disease is a common problem in multiple myeloma, although a variety of different mechanisms may be involved (43% in one series)
Myeloma cast nephropathy (myeloma kidney)
Primary amyloidosis
Light chain deposition disease
Renal tubular dysfunction" R: UPTODATE
#10
Re: amyloidosis agamamber - 02-26-08 12:04 hi sshahraz,
i know this is a tricky ques. even i answered it wrong. so i asked you all guys..
#14
Re: amyloidosis sshahraz - 02-26-08 15:54 agamamber, i do like tricky questions indeed! thanks for the question. could you please play around the answers a bit more and let us know why kidney can be the correct answer. i gave a piece of evidence that kidney is a common site to be invovled in mm. tnx in advance.
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