USMLE Forum Archives - USMLE Step 2 CK - auto immune
auto immune
conym5 - 12-28-09 09:29
A 35 yr old lady came to the emergency room with cmplaints of petechial rash, fever, headaches, fatigue for the last 2days .she denies any other complaints. Lab shows Inhibiting and non-inhibiting anti-ADAMTS13 autoantibodies are positive in high titers. what is the diagnosis?
conym5 - 12-28-09 09:29
A 35 yr old lady came to the emergency room with cmplaints of petechial rash, fever, headaches, fatigue for the last 2days .she denies any other complaints. Lab shows Inhibiting and non-inhibiting anti-ADAMTS13 autoantibodies are positive in high titers. what is the diagnosis?
The correct answer and explanation will be available after you answer.
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#5
Re: auto immune
conym5 - 12-28-09 15:49 ADAMTS13 (a disintegrin and metalloprotease with thrombospondin
motifs), a circulating multidomain zinc metalloprotease
of the reprolysin subfamily, is critical for preventing von Willebrand
factor-platelet interaction under high shear stress conditions.
A deficiency of the protease, due to mutations in the
ADAMTS13 gene or the presence of antibodies that inhibit the
activity of the protease, causes thrombotic thrombocytopenic purpura
(TTP).
#32
Re: auto immune ammulufy - 03-13-10 20:07 My answer is: b.
I go with TTP as my choice becos of d finding of petechial rashes.
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