USMLE Step 1 - deep truths on immunology
deep truths on immunology
bingousmle - 11-13-08 15:06
what does nitroblue tetrazolium test makes one think
bingousmle - 11-13-08 15:06
what does nitroblue tetrazolium test makes one think
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#1
Re: deep truths on immunology InSitu - 11-13-08 15:13 Blood test to diagnose Chronic Granulomatous Disease (CGD) of childhood.
#2
Re: deep truths on immunology usmlefever3 - 11-14-08 02:16 NBT test is a classical screening test for CGD.in this clourless dye gives blue colour if there is respiratory burst due to presence of enzyme NADPH oxidase at the cell membrane of phagocytes
#3
Re: deep truths on immunology
bingousmle - 11-14-08 02:42 you see a patient with bacterial infectionswith severe gingivitis and severe mucosal infections and with skin hypopigmentation with defect in microtubules and phagocytosis , what bug is most often the offending agent in these patints and what is the treatment
#4
Re: deep truths on immunology usmlefever3 - 11-14-08 04:53 it will be staph aureus in CGD as it is catalase postive which degrades any hydrogen peroxide formed in phagolysosome
#5
Re: deep truths on immunology bingousmle - 11-14-08 06:56 but the patient in this vignette is not suffering from CGD , whats the immunodeficiency disease he is suffering from, dear?
#6
Re: deep truths on immunology bingousmle - 11-16-08 00:50 well you are right on the account that he will have recurrent strpt and staph infections, but he is suffering from chediak higashi syndrome, how would you go about treating this patient?
#7
Re: deep truths on immunology turbojet - 11-17-08 12:14 SORRY,but i did not get y is it chediak higashi
#8
Re: deep truths on immunology bingousmle - 11-17-08 22:53 a defect in microtubule leads to failure of fusion of the lysosome and the phagosome.plus albinism is seen as an associated condition and though the mainstay remains antibiotics and surgical drainag eof absceeses , acyclovir is also used in these patients to boost immunity
#9
Re: deep truths on immunology bingousmle - 11-19-08 08:06 what are the various precursor proteins , resulting in amyloidosis in the following diseases:
for eg :B2microglobulin in chronic hemodialysis
rheumatoid arthritis
multiple myeloma
cardiac amyloidosis
alzeihmers
#10
Re: deep truths on immunology kingofhearts - 11-19-08 08:32 for multiple myeloma ----monoclonal proliferation of B-cells...for alzeihmers----AB(beta)............
for rheumatoid arthritis---HLA-DR4,HLA-DR1.....................I GUESS i am not wrong unless you correct me.....
#11
Re: deep truths on immunology bingousmle - 11-19-08 08:40 multiple myeloma-lambda chains
rheumatoid arthritis -serum amyloid associated protein
cardiac amyloidosis- transthyretin
amyloid precursor protein in alzeihmers
which genetic disorderis associated with the last condition
#12
Re: deep truths on immunology kingofhearts - 11-19-08 08:55 oh i badly misunderstood the question.....poor me.....
#13
Re: deep truths on immunology bingousmle - 11-19-08 12:05 no probs..
Downs syndrome is seen in Alzeihmers
a man is transfused blood following an accident in which he has lost a lot of blood . he develops anaphylactic reaction . the relative says that there is no significant history accept a few minor respiratory infections and occasional diarrhoea. what do you think he has?
#15
Re: deep truths on immunology bingousmle - 11-19-08 22:42 why on earth do you say that??just because he's got chronic diarrhoea and respiratory infections?
you need to justify why has he developed anaphylactic reaction to transfused blood
#16
Re: deep truths on immunology kingofhearts - 11-20-08 01:03 ok it is due to allergy to plasma products....and also may be due to mismatched blood..the allergy can be subsided with chlorpheniramine maleate....
#18
Re: deep truths on immunology bingousmle - 11-20-08 03:18 why do you say so?this man suffered an anaphylactic reaction after blood was tranfused.(hint its something to do with immunoglobulins)
but defiitely he is not immunocompromised..
#19
Re: deep truths on immunology kingofhearts - 11-20-08 08:39 igE mediated hypersensitivity reaction , which develops after introduction of a large shocking dose of antigen...........
#20
Re: deep truths on immunology bingousmle - 11-20-08 09:52 i ll not pull this any further...this man had IgA deficiency, which resulted in the recurrent infections of respiratory tract and diarrheas. but over a period of time they develop anti IgA antibodies which resulted in the anaphylactic reaction!
#22
Re: deep truths on immunology bingousmle - 11-21-08 09:53 you happen to see akid 2 yrs old with recurrent bacterial infections.the production of HOCL by neutrophils is ddecreased but hydrogen peroxide and OH radicals are normally produced. what enzyme deficiency are you suspecting?
#24
Re: deep truths on immunology bingousmle - 11-25-08 13:57 thats true. what is the metal ion in MPO
#26
Re: deep truths on immunology bingousmle - 11-26-08 08:27 myeloperoxidase contains heme as a prosthetic group, hence the metal ion is Fe
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