USMLE Forum Archives - USMLE Step 2 CK - DVT
DVT
conym5 - 03-11-10 09:17
36-yr-old womanevaluated for a proximal DVT of left lower extremity that developed 1 month ago. family history is +ve for protein S deficiency ,After 6 months of anticoagulation therapy with warfarin, treatment was discontinued. lab performed confirm that she is deficient in serum protein S but has no other prothrombotic defects. next step in the management?
conym5 - 03-11-10 09:17
36-yr-old womanevaluated for a proximal DVT of left lower extremity that developed 1 month ago. family history is +ve for protein S deficiency ,After 6 months of anticoagulation therapy with warfarin, treatment was discontinued. lab performed confirm that she is deficient in serum protein S but has no other prothrombotic defects. next step in the management?
The correct answer and explanation will be available after you answer.
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#4
Re: DVT
conym5 - 03-11-10 20:32 If the first thrombotic event was life threatening or occurred in multiple or unusual sites (eg, cerebral veins, mesenteric veins), most experts recommend lifelong therapy initially.
otherwise only 6months is enough..
#16
Re: DVT mtniharika - 04-30-10 08:36 My answer is: b.
Management of protein S deficiency takes place in the event of acute VTE or in patients with asymptomatic carrier states without a thrombotic event. Following an acute thrombosis, administer heparin therapy and then transition to warfarin oral anticoagulation.
#18
Re: DVT babbu5508 - 05-20-10 15:13 My answer is: b.
Following an acute thrombosis, administer heparin therapy and then transition to warfarin oral anticoagulation.The question of whether to continue lifelong warfarin in patients with identified protein S deficiency after their first thrombotic event is controversial.
#37
Re: DVT babbu5508 - 09-30-10 16:33 long term anticoagulant therapies have shown no higher benefit in asymptomatic cases of protein s deficiency............
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