Re: ENDO.
InSitu - 11-27-08 20:54

Open for discussion.

Re: ENDO.
bingousmle - 11-28-08 00:12

hi. growth hormone can be considered as an anabolic hormone. alll its efforts are concentrated towards promoting growth, for which it is essential to have fuel. growth hormone plays a role in maintaining fuel homeostasis.it promotes hepatic gluconeogenesis, decreases hepatic uptake of glucose , promotes lipolysis so that there is enough fuel and increases protein synthesis to promote growth.

now , in acromegaly you have surplus GH,and so it will result in hyperglycemia and a relative insulin resistance-->DM

hypoglycemia on the other hand is a trigger for the release of GH, not th other way round..

Re: ENDO.
usmlefever3 - 11-28-08 01:12

yes GH has both anabolic and catabolic effects
catabolic- anti insulin effects
anabolic-increase amino acid uptake and through IGF-1
IGF-1 insulin like growth factor which increases the length of the bones

now how could we differentiate between dwarfism due to GH def and IGF-1 def

Re: ENDO.
bingousmle - 11-28-08 03:36

the two disorders could be differentiated by their response to growth hormone therapy. GH would be ineffective in the latter condition...just a guess

Re: ENDO.
usmlefever3 - 11-28-08 14:48

normal growth hormone but decreased IGF-1 is laron synd which has dwarfism.dwarfism is also due to growth hormone def.
both can be differentiated by measuring just glucose levels which will be norma in laron syndrome as growth hormone level is normal