USMLE Forum Archives - USMLE Step 2 CK - endocrin
endocrin
ysemak - 01-04-10 18:58
You see a girl with short stature. After obtaining a bone age you find that the growth plates have fused. Which of the following hormones is responsible for growth plate fusion?
ysemak - 01-04-10 18:58
You see a girl with short stature. After obtaining a bone age you find that the growth plates have fused. Which of the following hormones is responsible for growth plate fusion?
The correct answer and explanation will be available after you answer.
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#2
Re: endocrin mtniharika - 01-05-10 05:08 My answer is: d.
The growth plate cartilage is replaced by bone. This process is termed epiphyseal fusion. Estrogen is pivotal for epiphyseal fusion in both young men and women. This key role for estrogen was confirmed recently with the recognition of two genetic disorders, estrogen deficiency due to mutations in the aromatase gene and estrogen resistance due to mutations in the estrogen receptor-alpha gene. In both of these conditions, the growth plate fails to fuse and growth persists, albeit slowly, into adulthood.
#3
Re: endocrin conym5 - 01-05-10 09:22 My answer is: d.
Estrogen treatment accelerated the senescent decline in all of these parameters. In senescent growth plates, epiphyseal fusion was observed to be an abrupt event in which all remaining chondrocytes were rapidly replaced by bone elements.
#15
Re: endocrin ammulufy - 03-13-10 18:47 My answer is: d.
Estrogen is responsible for all the pubertal and post-pubertal changes.
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