USMLE Forum Archives - USMLE Step 1 - GFR, RPF and FF
GFR, RPF and FF
drspleen - 03-17-11 18:36
A patient takes a large dose of ketorolac for muscular pain. He subsequently develops oliguria and referred to a nephrologist. The nephrologist is concerned that ketorolac may have caused acute renal failure and predicts that measurements of GFR, RPF and FF will be:
* A. GFR decreased, RPF decreased, FF no change
* B. GFR decreased, RPF no change, FF decreased
* C. GFR no change, RPF decreased, FF decreased
* D. GFR decreased, RPF increased, FF decreased
* E. GFR no change, RPF no change, FF increased
drspleen - 03-17-11 18:36
A patient takes a large dose of ketorolac for muscular pain. He subsequently develops oliguria and referred to a nephrologist. The nephrologist is concerned that ketorolac may have caused acute renal failure and predicts that measurements of GFR, RPF and FF will be:
* A. GFR decreased, RPF decreased, FF no change
* B. GFR decreased, RPF no change, FF decreased
* C. GFR no change, RPF decreased, FF decreased
* D. GFR decreased, RPF increased, FF decreased
* E. GFR no change, RPF no change, FF increased
The correct answer and explanation will be available after you answer.
Page 1
#3
Re: GFR, RPF and FF babbu5508 - 03-18-11 19:14 My answer is: b.
B. GFR decreased, RPF no change, FF decreased...because its effect is on the kidneys but not on its vascualature
#4
Re: GFR, RPF and FF sudha2015 - 03-19-11 10:21 A patient takes a large dose of ketorolac for muscular pain. He subsequently develops oliguria and referred to a nephrologist. The nephrologist is concerned that ketorolac may have caused acute renal failure and predicts that measurements of GFR, RPF and FF will be
b
#5
Re: GFR, RPF and FF
drspleen - 03-21-11 18:41 NSAIDs such as ketorolac may precipitate acute renal failure by decreasing prostaglandin production through the COX-2 enzyme inhibition. Normally, prostaglandin maintains glomerular capillary pressure and blood flow by dilating the afferent arterioles. Without prostaglandin, the afferent arterioles do not dilate and glomerular capillary pressure is inadequate to sustain normal GFR.
Page 1