USMLE Forum Archives - USMLE Step 3 - HY Explanations
HY Explanations
harry206 - 05-09-09 02:53
Why unfractionated heparin during labour and delivery than LMWH?
why its better to give LMWH during pregnancy than unfractionated heparin?
Unfractionated heparin:
- has a high molecular weight which precludes transplacental transfer.
- devoid of known teratogenic risk and does not anticoagulate the fetus
so used in labour and delievery.
BUT
- relative difficulty of maintaining a stable therapeutic response
- inconvenience of parenteral administration,
- complications of heparin-induced thrombocytopenia
Because of this reasons Unfractionated heparin not used in pregnancy
LMW heparin may resolve the difficulty in achieving a sustained, stable therapeutic response and may reduce the inconvenience of parenteral administration (increased bioavailability and a longer half-life)
harry206 - 05-09-09 02:53
Why unfractionated heparin during labour and delivery than LMWH?
why its better to give LMWH during pregnancy than unfractionated heparin?
Unfractionated heparin:
- has a high molecular weight which precludes transplacental transfer.
- devoid of known teratogenic risk and does not anticoagulate the fetus
so used in labour and delievery.
BUT
- relative difficulty of maintaining a stable therapeutic response
- inconvenience of parenteral administration,
- complications of heparin-induced thrombocytopenia
Because of this reasons Unfractionated heparin not used in pregnancy
LMW heparin may resolve the difficulty in achieving a sustained, stable therapeutic response and may reduce the inconvenience of parenteral administration (increased bioavailability and a longer half-life)
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Re: HY Explanations
harry206 - 05-09-09 02:56 Recurrent pyelonephritis during pregnancy
Once afebrile for 48 hours, patients can be switched to oral therapy & discharged to complete 10 to 14 days of treatment.
Recurrent pyelonephritis during pregnancy occurs in 6 to 8 % .------> so low dose antimicrobial prophylaxis, (nitrofurantoin or cephalexin at bedtime), and periodic urinary surveillance for infection are recommended for the remainder of the pregnancy
#2
Re: HY Explanations usmlefever3 - 05-09-09 03:42 thanks...nice facts about administering heparin in pregnancy
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