USMLE Forum Archives - USMLE Step 3 - Hydrochlorothiazide
Hydrochlorothiazide
zkadhem - 06-07-09 12:27 Bookmark and Share

Patient on hydrochlorothiozide found to have high uric acid. Next step?
Patient on hydrochlorothiazide developed gout attack or renal calculi.Next step?

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#1
Re: Hydrochlorothiazide
fas148 - 06-07-09 13:03

stop hydrochlorthiazed

#2
Re: Hydrochlorothiazide
zkadhem - 06-07-09 14:03

In the first question, no you will not stop HTCZ.You don't treat asymptomatic hyperuricemia.
In the second question, yes you have to stop the drug.

#3
Re: Hydrochlorothiazide
sabiraghauri - 06-07-09 15:17

if it is just increase in uric acid, no treatment.just follow closely
if it is gout stop HCTZ and treat the gout.

#4
Re: Hydrochlorothiazide
mtniharika - 11-21-09 10:28

yup i agree with the above.
Side effects of hctz:
Hypokalemia
Hypomagnesemia
Hyperuricemia and gout
High blood sugar
Hyperlipidemia
Hypercalcemia
Headache
Nausea/vomiting
Photosensitivity
Weight Gain

#5
Re: Hydrochlorothiazide
babbu5508 - 02-23-11 02:11

The major site of action in the nephron appears on an electroneutral Na+-Cl- co-transporter by competing for the chloride site on the transporter. By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss.

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