Re: Hypercalcemia
mohhaider - 10-22-08 23:59

Loop diuretics like frusemide that will increase calicium urinary excreation ,but it needs agresive fluid hydration .This is what can I recall from hypercalcemia.

Re: Hypercalcemia
bobby - 10-23-08 00:09

You are right.
Adequate hydration with 0.9% NaCl followed by diuretic like Frusemide.This is adequate for mild to moderate hypercalcemia ,but not for severe cases.
For severe cases--addition of calcitonin is essential.

Re: Hypercalcemia
sackatdoc - 10-25-08 10:40

loops- loose
thiazides retain calcium, too much high yeild this is asked so many times

Re: Hypercalcemia
bingousmle - 10-25-08 13:57

from what i have read bisphosphonates are drugs of choice for hypercalcemia of malignancy. what is the anticancer drug which can cause hypocalcemia

Re: Hypercalcemia
sackatdoc - 10-25-08 14:19

what has been described above is emergent treatment,given I.V.,and bisphosphonates ar also given
AMIFOSTINE is the drug that causes serum ca to fall

Re: Hypercalcemia
bobby - 10-25-08 14:23

I am not sure about Biphosphonates being the drug of choice.But yes it is definately used.
Anti cancer drugs causing hypocalcemia-
1. Mithramycin(plicamycin)--Was used to treat metastaic testicular cancer.Now used to treat testicular ca which has become resistant to other treatment.Very rarely used due to toxicity.
2. Cisplatin--causes hypomagnesemia which may may induce hypocalcemia.
3. 5 FU and low dose leucovorin use.

Re: Hypercalcemia
bingousmle - 10-25-08 17:58

thanks i wasnt aware of the remaining two

Re: Hypercalcemia
bobby - 10-25-08 18:02

You are welcome.But I am not aware of the mechanism by which they cause hypocalcemia.Can anyone highlight on that?

Re: Hypercalcemia
moazzamhyder - 11-18-08 08:06

fluid iv first loop diuretics thiazides contraindicated others t/t plicamycin bi phosphonates calcitonin prednisone is imp gallium nitrate

Re: Hypercalcemia
kingofhearts - 11-19-08 04:32

iv biphosphonates (pamidronate,sodium etidronate,zoledronic acid) are useful in malignancy asscociated hypercalcaemia...these agents inhibit osteoclast action,thereby reducing bone resorption.....