IM 25
Brainlab - 12-11-06 09:58 Bookmark and Share

A 70-year-old woman has been in long-standing poor health, with severe diabetes mellitus and rheumatoid arthritis. Her physician notes that she appears pale and orders a hematocrit, which shows a result of 35%. Examination of the blood smear reveals a microcytic anemia. The physician is considering a differential diagnosis of iron deficiency anemia versus anemia of chronic disease. Which of the following laboratory determinations would be most helpful in distinguishing these conditions?

A. Erythrocyte:granulocyte ratio in bone marrow
B. Presence or absence of polychromatophilic target cells
C. Presence or absence of stippled erythrocytes
D. Serum ferritin
E. Serum iron

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#1
Re: IM 25
TheOne - 12-11-06 12:12

D
Iron deficiency anemia = low Serum ferritin.

Anemia of chronic disease = normal (or high) Serum ferritin.

#2
Re: IM 25
drs_kh - 12-12-06 04:11

D

#3
Re: IM 25
Brainlab - 12-15-06 15:38

Correct!

#4
Re: IM 25
ammulufy - 07-07-10 22:08

C

#5
Re: IM 25
babbu5508 - 07-07-10 22:12

D. Serum ferritin
low serum ferritin would be found in iron deficiency anaemia but not anaemia of chronic disease....so diagnostic...

#6
Re: IM 25
bingousmle - 07-11-10 02:33

Serum ferritin is the most essential test to rely on for distinguishing between anemia of chronic disease and that due to iron deficiency

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