USMLE Forum Archives - USMLE Step 3 - IM: The most likely diagnosis
IM: The most likely diagnosis
meduploader - 05-31-09 14:49
A 26-year-old woman who has been exposed to gonorrhea and is asymptomatic is treated with 1 gram probenecid (Benemid) and 4.8 million units of intramuscular procaine penicillin. Within 1 minute the patient becomes extremely combative, agitated, hallucinative, and anxious, and screams that she is going to die. Vital signs are normal except for a pulse rate of 120/min. Within 15 minutes, the patient is calm and asks what happened. The most likely diagnosis of this condition is:
meduploader - 05-31-09 14:49
A 26-year-old woman who has been exposed to gonorrhea and is asymptomatic is treated with 1 gram probenecid (Benemid) and 4.8 million units of intramuscular procaine penicillin. Within 1 minute the patient becomes extremely combative, agitated, hallucinative, and anxious, and screams that she is going to die. Vital signs are normal except for a pulse rate of 120/min. Within 15 minutes, the patient is calm and asks what happened. The most likely diagnosis of this condition is:
The correct answer and explanation will be available after you answer.
Page 1
#6
Re: IM: The most likely diagnosis
conym5 - 06-18-09 13:21 My answer is: d.
Probenecid may increase the plasma concentrations and half-lives of penicillins. The mechanism is competitive inhibition by probenecid of the renal tubular secretion of penicillins. While this interaction is often exploited to enhance the antibacterial effect of penicillins, toxicity may occur and should be considered if high penicillin dosages are administered intravenously.
#16
Re: IM: The most likely diagnosis
conym5 - 04-09-10 08:29 Reactions are transient, lasting from 15 to 30 minutes, and may be treated with parenteral physostigmine. Probenecid and penicillin are not known to produce such reactions.
#25
Re: IM: The most likely diagnosis
babbu5508 - 08-30-10 03:54 My answer is: c.
treated with 1 gram probenecid (Benemid) and 4.8 million units of intramuscular procaine penicillin. Within 1 minute the patient becomes extremely combative, agitated, hallucinative, and anxious, and screams that she is going to die
Page 1






