USMLE Forum Archives - USMLE Step 3 - IM15
IM15
bingousmle - 07-28-10 02:06
Rifampin lowers serum levels of all of the followingmedicines except
A. amiodarone
B. anticonvulsants
C. oyclosporine
D. hormonal contraceptives
E. warfarin
bingousmle - 07-28-10 02:06
Rifampin lowers serum levels of all of the followingmedicines except
A. amiodarone
B. anticonvulsants
C. oyclosporine
D. hormonal contraceptives
E. warfarin
The correct answer and explanation will be available after you answer.
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#1
Re: IM15 babbu5508 - 07-28-10 03:26 My answer is: a.
The concomitantly administered effects of rifampicin on other drugs can result in their altered metabolism or transportation that are metabolised by cytochromes P450
#2
Re: IM15
bingousmle - 07-28-10 11:10 My answer is: a.
Rifampin is considered the most potent and important antituberculosis drug. Rifampin is a potent P450 CY3PA inducer and may lower the half-life and therefore effective levels of many important drugs
#5
Re: IM15 babbu5508 - 08-30-10 23:58 Rifampicin has significant interactions with warfarin, oral contraceptives, cyclosporine, itraconazole, digoxin, verapamil, nifedipine, simvastatin, midazolam and HIV protease inhibitors. Other possible interactions include antiretroviral agents, everolimus, atorvastatin, rosiglitazone/pioglitazone, celecoxib, clarithromycin, caspofungin, and lorazepam
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