USMLE Forum Archives - USMLE Step 1 - mdp19
mdp19
babbu5508 - 06-01-11 00:38
Another drug prescribed for this patient is tolcapone. Which of the following is the mechanism of action of this agent?
/ A. COMT inhibitor
/ B. Dopamine agonist
/ C. Dopamine uptake blocker
/ D. MAO inhibitor
/ E. Muscarinic antagonist
/ F. Selective serotonin reuptake inhibitor
babbu5508 - 06-01-11 00:38
Another drug prescribed for this patient is tolcapone. Which of the following is the mechanism of action of this agent?
/ A. COMT inhibitor
/ B. Dopamine agonist
/ C. Dopamine uptake blocker
/ D. MAO inhibitor
/ E. Muscarinic antagonist
/ F. Selective serotonin reuptake inhibitor
The correct answer and explanation will be available after you answer.
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#1
Re: mdp19 dinmenace - 06-04-11 00:30 My answer is: a.
Tolcapone inhibits the COMT enzyme, which degrades dopamine, thereby prolonging the effects of levodopa.It has been used to complement levodopa; however, its usefulness is limited by possible side effects such as liver damage
#2
Re: mdp19
babbu5508 - 06-16-11 01:19 The correct answer is A. Tolcapone and entacapone are COMT inhibitors, which prevent the peripheral conversion of L-Dopa to 3-O-methyldopa, enhancing the availability of L-Dopa for transport across the blood-brain barrier. These drugs are used as adjuncts to levodopa-carbidopa and can prolong "on-time" and allow lower doses of L-Dopa to be used.
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