USMLE Forum Archives - USMLE Step 1 - mdp2
mdp2
babbu5508 - 05-31-11 23:56
Where are the primary sites of cell degeneration in this patient's disease?
/ A. Basal ganglia and thalamus
/ B. Frontal and temporal cortical regions
/ C. Neostriatum and cerebral cortex
/ D. Substantia nigra pars compacta and locus coeruleus
/ E. Upper and lower motor neurons
babbu5508 - 05-31-11 23:56
Where are the primary sites of cell degeneration in this patient's disease?
/ A. Basal ganglia and thalamus
/ B. Frontal and temporal cortical regions
/ C. Neostriatum and cerebral cortex
/ D. Substantia nigra pars compacta and locus coeruleus
/ E. Upper and lower motor neurons
The correct answer and explanation will be available after you answer.
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#1
Re: mdp2 dinmenace - 06-01-11 19:52 My answer is: c.
Damage mainly occurs in the striatum, but as the disease progresses, other areas of the brain are also significantly affected. As the damage accumulates, symptoms associated with the functions of these brain areas appear. Planning and modulating movement are the main functions of the striatum, and difficulties with these are initial symptoms.
#2
Re: mdp2
babbu5508 - 06-16-11 01:27 The correct answer is C. Cell death in the caudate and putamen (neostriatum) produces the chorea. Release of the globus pallidus from striatal inhibition results in suppression of subthalamic activity, which may also contribute to the choreiform movements
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