USMLE Forum Archives - USMLE Step 1 - mdp3
mdp3
babbu5508 - 05-31-11 23:56
Which of the following is the most appropriate pharmacotherapy for this patient?
/ A. Acetylcholinesterase inhibitors
/ B. Anticholinergics
/ C. Dopamine antagonists
/ D. Dopamine precursors
/ E. Thiamine
babbu5508 - 05-31-11 23:56
Which of the following is the most appropriate pharmacotherapy for this patient?
/ A. Acetylcholinesterase inhibitors
/ B. Anticholinergics
/ C. Dopamine antagonists
/ D. Dopamine precursors
/ E. Thiamine
The correct answer and explanation will be available after you answer.
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#1
Re: mdp3 dinmenace - 06-01-11 19:54 My answer is: b.
Tetrabenazine was developed specifically to reduce the severity of chorea in HD, it was approved in 2008 for this use in the US. Other drugs that help to reduce chorea include neuroleptics and benzodiazepines. Compounds such as amantadine or remacemide are still under investigation but have shown preliminary positive results
#4
Re: mdp3
babbu5508 - 06-16-11 01:28 The correct answer is C. Although, no therapy is currently available to delay the onset of symptoms or to prevent the progression of the disease, symptomatic treatment of HD patients may improve the quality of life and prevent complications. Dopamine antagonists (antipsychotic agents) are used for the psychosis, paranoia, and delusional states that occur in HD, although they are used in lower doses than is often required for primary psychiatric disorders.
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