USMLE Forum Archives - USMLE Step 1 - mpp19
mpp19
babbu5508 - 05-31-11 23:42
Administration of which of the following hormones might have prevented this patient's condition?
/ A. Follicle stimulating hormone
/ B. Human chorionic gonadotropin
/ C. Insulin
/ D. Progesterone
/ E. Testosterone
babbu5508 - 05-31-11 23:42
Administration of which of the following hormones might have prevented this patient's condition?
/ A. Follicle stimulating hormone
/ B. Human chorionic gonadotropin
/ C. Insulin
/ D. Progesterone
/ E. Testosterone
The correct answer and explanation will be available after you answer.
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#1
Re: mpp19 dinmenace - 06-01-11 12:36 My answer is: d.
The most common subtype, endometrioid adenocarcinoma, typically occurs within a few decades of menopause, is associated with excessive estrogen exposure, often develops in the setting of endometrial hyperplasia, and presents most often with vaginal bleeding.
#2
Re: mpp19
babbu5508 - 06-16-11 01:06 The correct answer is D. One hypothesis for the development of endometrial cancer is that unopposed estrogen leads to the proliferation and eventual cancerous change of the endometrial lining. It has been well-demonstrated that postmenopausal women who have a uterus (i.e., postmenopausal women who have not had a hysterectomy) have an increased probability of developing endometrial cancer that correlates directly with the dose and duration of unopposed estrogen use. The increased risk has also been shown to persist even after the estrogen has been stopped. "Unopposed" estrogen refers to estrogen that is not opposed by progesterone. This patient has no past surgical history, that is, she has never had a hysterectomy. She was taking unopposed estrogen during her 50s. She should have also been on a progestin at that time to prevent the development of endometrial cancer.
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