USMLE Forum Archives - USMLE Step 1 - NEPHROTIC vs NEPHRITIC SYNDROME
NEPHROTIC vs NEPHRITIC SYNDROME
drspleen - 03-17-11 17:45
Membranous glomerulonephritis is often associated with which condition?
* A. Hep B
* B. Hep D
* C. Hep A
* D. Hep E
* E. None of the above
drspleen - 03-17-11 17:45
Membranous glomerulonephritis is often associated with which condition?
* A. Hep B
* B. Hep D
* C. Hep A
* D. Hep E
* E. None of the above
The correct answer and explanation will be available after you answer.
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#3
Re: NEPHROTIC vs NEPHRITIC SYNDROME babbu5508 - 03-18-11 19:24 My answer is: a.
membranous glomerulonephritis is associated with hepatitis B and C and similar association is with PAN...
#4
Re: NEPHROTIC vs NEPHRITIC SYNDROME sudha2015 - 03-19-11 10:19 Membranous glomerulonephritis is often associated with which condition?
* A. Hep B
* B. Hep D
* C. Hep A
* D. Hep E
* E. None of the above
a
#5
Re: NEPHROTIC vs NEPHRITIC SYNDROME
drspleen - 03-21-11 18:43 Although most cases of membranous glomerulonephritis (membranous nephropathy) are primary idiopathic, there are a variety of causes of secondary membranous nephropathy. These include: Infectious diseases: - Hepatitis B - Hepatitis C - Syphilis - Malaria Autoimmune diseases: - Systemic lupus erythematosus - Rheumatoid arthritis - Sjögren's syndrome - Hashimoto thyroiditis Drugs: - Penicillamine - Captopril - NSAIDs - Gold Malignancy: - Solid tumors (eg, colon carcinoma, lung carcinoma, melanoma) - Chronic lymphocytic leukemia Nevertheless, 85% of the membranous glomerulonephritis cases are classified as primary idiopathic with no identifiable culprit. In a context of a known intravenous drug abuser who develops nephrotic syndrome, it is important to consider transmission of hepatitis B or hepatitis C and the subsequent development of membranous glomerulonephritis. The pathophysiology is believed to involve circulating immune complexes which bind to in situ antigens on the glomerular epithelial basement membrane with activation of complement cascade → C5b-C9 membrane attack complex damages glomerular epithelial and mesangial cells, causing their release of proteases and oxidants which further contribute to capillary wall damage and subsequent nephrotic-range proteinuria.
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