Re: NSAIDS and GI upset
urkhan - 01-19-08 06:49

Protaglandin inibitors..
C/I
old pt,renal insufficiency,bleeding disorder, hemorrhagic stroke,children..

Re: NSAIDS and GI upset
radhamesramos - 01-22-08 13:20

and pregnant women

Re: NSAIDS and GI upset
InSitu - 01-22-08 13:54



Name of the drug in specific? plz :)

Re: NSAIDS and GI upset
laparotomy - 01-26-08 13:30

First of all I would not give patients NSAIDs if they had GI upset. If I really had to then I would put them on a PPI for e.g Omeprazole

Re: NSAIDS and GI upset
radhamesramos - 01-26-08 15:55

Misoprostol or Cytotec (TM)

Re: NSAIDS and GI upset
laparotomy - 01-27-08 05:16

I think Omeprazole is better.

May I refer you to: The New England Journal of Medicine 1998 Mar 12;338(11):727-34.
Titled "Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs."
By the Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group.Hawkey CJ, Karrasch JA, Szczepañski L, Walker DG, Barkun A, Swannell AJ, Yeomans ND.
Division of Gastroenterology, University Hospital, Nottingham, United Kingdom.

They concluded:
CONCLUSIONS: The overall rates of successful treatment of ulcers, erosions, and symptoms associated with NSAIDs were similar for the two doses of omeprazole and misoprostol. Maintenance therapy with omeprazole was associated with a lower rate of relapse than misoprostol. Omeprazole was better tolerated than misoprostol.

Can you give me scientific literature supporting the use of misoprostol against PPI? Thanks.

Re: NSAIDS and GI upset
radhamesramos - 01-28-08 12:00

Thanks for the article...I rarely use misoprostol, I just said the name because somebody asked for it...but PPI are the DOC..I rarely use Misoprostol for the side effects and CIs

Re: NSAIDS and GI upset
laparotomy - 01-28-08 15:15



You are welcome