USMLE Forum Archives - USMLE Step 1 - Oxidative phorphorylation
Oxidative phorphorylation
sshahraz - 02-22-08 21:07 Bookmark and Share

Two of the following substances share the same mechanism to block the electron transport chain which are:
A. Cyanide and CO
B. Antimycin and CO
C. Cyanide and aspirin
D. Rotenone and aspirin
E. DNP and Rotenon

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#1
Re: Oxidative phorphorylation
matilda - 02-22-08 23:07

A.Cyanide and CO block Cytochrome oxidase

#2
Re: Oxidative phorphorylation
agamamber - 02-23-08 07:54

A

#3
Re: Oxidative phorphorylation
sshahraz - 02-23-08 12:12

YES!!
A is correct. CO AND CYNAIDE!
The other couple that you can think of are ASPIRIN AND DNP that block uncoupling reagent and produce a lot of heat. ROTENON blocks complex 1 , doxorubicin inhibits coenzyme Q, ANTIMYCIN blocks cytochrome b/c1 and finally oligomycin stops F0.

#4
Re: Oxidative phorphorylation
radhamesramos - 02-23-08 18:27

Very HY! Might appear a case that somebody posions him/herself from it, and you got to get the cause of it or the mechanism. Which is similar in both, so have to correlate them

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