Re: Pathology 19
kingkong - 10-19-06 03:35

(A) could be the answer.not sure.please explain.

Re: Pathology 19
preethy - 10-19-06 15:36

option c

need to know
preethy - 10-19-06 16:06

when do i need to start preparing for us mle?? I am in my 3rd yr now...

Re: Pathology 19
TheOne - 10-20-06 17:25

Explanation: The correct answer is C. Libman-Sacks endocarditis affects patients with systemic lupus erythematosus (SLE). Small granular vegetations consisting of fibrin develop on the undersurface of the leaflets of mitral and aortic valves. Fragments of vegetations may detach, resulting in embolism. Eventually, vegetations heal by organization of fibrin and subsequent fibrosis, leading to distortion of valve leaflets and resultant insufficiency or stenosis. The pathogenesis is unclear but is probably related to thrombotic diathesis. Hemorrhagic pericarditis (choice A) is usually a consequence of tuberculosis or metastatic spread of cancer to the pericardium. An exudate containing blood accumulates in the pericardial sac, producing pain and a characteristic auscultatory phenomenon known as a pericardial rub. SLE is associated instead with fibrinous pericarditis, which also manifests with chest pain and pericardial rub. Infective endocarditis (choice B) is prevalent in patients with damaged or prosthetic valves and in intravenous drug abusers. It is associated with formation of bulky, friable vegetations that consist of masses of fibrin, neutrophils, and bacteria. Such vegetations cause extensive destruction of valve leaflets and may release fragments into the bloodstream, with resultant septic embolism. There is no association between SLE and mitral valve prolapse (choice D), which is a frequent, usually asymptomatic, valvular abnormality that occurs in 2% to 3% of the general population. Mitral valve prolapse is also associated with Marfan syndrome. Complications include sudden death, thromboembolism, and mitral regurgitation. Myocardial fibrosis (choice E) does not occur in SLE. It develops in progressive systemic sclerosis, a collagenopathy characterized by extensive fibrosis in many organs, especially skin, lungs, and gastrointestinal tract. The heart is involved in 30% of cases. Myocardial fibrosis may cause arrhythmias.

Re: Pathology 19
TheOne - 10-20-06 17:45

hi Preethy,
It really depends on you when to start the preparation for the usmle, for step 1, if you can start preparing right now is better, while the informations are still fresh in your mind.
For step 2, as soon as you graduate.
Anyone wants to share his ideas ?

Re: Pathology 19
galaxy - 05-27-10 19:22

Which of the following cardiac complications may develop in a 33-year-old woman with systemic lupus erythematosus (SLE) because of her underlying condition?

C. Libman-Sacks endocarditis

Re: Pathology 19
babbu5508 - 06-21-10 14:58

C. Libman-Sacks endocarditis is a form of nonbacterial endocarditis that is seen in systemic lupus erythematosus.......

Re: Pathology 19
bingousmle - 06-30-10 22:23

in SLE Small granular vegetations consisting of fibrin develop on the undersurface of the leaflets of mitral and aortic valves. libman sack disease..

Re: Pathology 19
leenamathew1 - 07-04-10 07:08

c

Re: Pathology 19
ktkmelody - 07-20-10 09:18

Yes, the correct answer is C.