USMLE Forum Archives - USMLE Step 1 - Pathology 20
Pathology 20
TheOne - 10-20-06 17:34
A 54-year-old woman with chronic microcytic hypochromic anemia also has a sore, smooth, red tongue and a sense of dysphagia midway during swallowing. This patient is at increased risk for developing which of the following conditions?
A. Adenocarcinoma of the esophagus
B. Barrett's esophagus
C. Candida esophagitis
D. CMV esophagitis
E. Squamous cell carcinoma of esophagus
TheOne - 10-20-06 17:34
A 54-year-old woman with chronic microcytic hypochromic anemia also has a sore, smooth, red tongue and a sense of dysphagia midway during swallowing. This patient is at increased risk for developing which of the following conditions?
A. Adenocarcinoma of the esophagus
B. Barrett's esophagus
C. Candida esophagitis
D. CMV esophagitis
E. Squamous cell carcinoma of esophagus
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#1
Re: Pathology 20 mosaabma - 10-21-06 18:27 The answer is E. Squamous cell carcinoma of esophagus
This patient has Plummer-Vinson syndrome, also called Paterson-Kelly syndrome or sideropenic dysphagia. It is a disorder linked to severe, long-term iron deficiency anemia, which causes swallowing difficulty (dysphagia) due to web-like membranes of tissue growing in the throat (esophageal webs). The cause of Plummer-Vinson syndrome is unknown; however, genetic factors and nutritional deficiencies may play a role. Women are at higher risk than men, particularly in middle age. The disease is named after two Americans, the physician Henry Stanley Plummer, and the surgeon Porter Paisley Vinson. There is risk of perforation of the esophagus with the use of dilators for treatment. There have been reports of an association between Plummer-Vinson syndrome and Squamous cell carcinoma of esophagus.
#2
Correct
TheOne - 10-24-06 15:05 Explanation: The correct answer is E. The patient has Plummer-Vinson syndrome, characterized by atrophic glossitis, esophageal webs, and iron-deficiency anemia. Patients with this syndrome are at increased risk of developing squamous cell carcinoma of the esophagus. Barrett's esophagus (choice B) and adenocarcinoma of the esophagus (choice A) are associated with reflux esophagitis. Candida(choice C) and CMV (choice D) esophagitis can be seen in immunosuppressed patients, including AIDS patients.
#3
Re: Pathology 20 galaxy - 05-27-10 19:24 A 54-year-old woman with chronic microcytic hypochromic anemia also has a sore, smooth, red tongue and a sense of dysphagia midway during swallowing. This patient is at increased risk for developing which of the following conditions?
E. Squamous cell carcinoma of esophagus is common in PVS.
#4
Re: Pathology 20 babbu5508 - 06-21-10 15:02 E. Squamous cell carcinoma of esophagus is common in plummer-vinson syndrome with development of esophageal webs in post cricoid area
#5
Re: Pathology 20 bingousmle - 06-30-10 22:21 Plummer-Vinson syndrome, characterized by atrophic glossitis, esophageal webs, and iron-deficiency anemia has a risk for developing SCC of esophagus
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