USMLE Forum Archives - USMLE Step 1 - Pathology 25
Pathology 25
TheOne - 11-04-06 18:06
A patient with familial hypercholesterolemia undergoes a detailed serum lipid and lipoprotein analysis. Studies demonstrate elevated cholesterol in the form of increased LDL without elevation of other lipids. This patient's hyperlipidemia is best classified as which of the following types?
A. Type 1
B. Type 2a
C. Type 2b
D. Type 3
E. Type 5
TheOne - 11-04-06 18:06
A patient with familial hypercholesterolemia undergoes a detailed serum lipid and lipoprotein analysis. Studies demonstrate elevated cholesterol in the form of increased LDL without elevation of other lipids. This patient's hyperlipidemia is best classified as which of the following types?
A. Type 1
B. Type 2a
C. Type 2b
D. Type 3
E. Type 5
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#1
Re: Pathology 25 nrp - 11-05-06 07:06 B.Type 2a is familial hypercholestrolemia due to increased LDL in blood.The deficiency is in apoB100 receptors.
#2
Re: Pathology 25 Youngdoctor - 11-05-06 22:15 B.Type 2a is familial hypercholestrolemia due to increased LDL in blood.The deficiency is in apoB100 receptors.
What about other classes, can you expain to me.
#3
Re: Pathology 25
TheOne - 11-06-06 11:01 Explanation: The correct answer is B. Hyperlipidemia has been subclassified based on the lipid and lipoprotein profiles. Type 2a, which this patient has, can be seen in a hereditary form, known as familial hypercholesterolemia, and also in secondary, acquired forms related to nephritic syndrome and hypothyroidism. The root problem appears to be a deficiency of LDL receptors, which leads to a specific elevation of cholesterol in the form of increased LDL. Heterozygotes for the hereditary form generally develop cardiovascular disease from 30 to 50 years of age. Homozygotes may have cardiovascular disease in childhood. Type 1 (choice A) is characterized by isolated elevation of chylomicrons. Type 2b (choice C) is characterized by elevations of both cholesterol and triglycerides in the form of LDL and VLDL. Type 3 (choice D) is characterized by elevations of triglycerides and cholesterol in the form of chylomicron remnants and IDL. Type 5 (choice E) is characterized by elevations of triglycerides and cholesterol in the form of VLDL and chylomicrons.
#4
Re: Pathology 25 galaxy - 05-28-10 02:04 B.Type 2a is familial hypercholestrolemia due to isolated increased LDL in blood....and is one of the dangerous types of hyperlipidemias.
#5
Re: Pathology 25 babbu5508 - 06-21-10 15:18 B. Type 2a due to LDL receptor deficiency causing increased LDL treated by Bile acid sequestrants, statins, niacin...
#6
Re: Pathology 25 bingousmle - 06-30-10 22:10 Type 2a is a deficiency of LDL receptors, which leads to a specific elevation of cholesterol in the form of increased LDL cholesterol
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