USMLE Forum Archives - USMLE Step 1 - Pathology 27
Pathology 27
TheOne - 11-04-06 18:09
A 22-year-old male presents with complaints of dull lower back pain and morning stiffness. The pain was initially episodic, but now has become persistent and bilateral. On physical examination, there is tenderness over the costosternal junctions, spinous processes of the vertebrae, and the iliac crests. Which of the following tests would be most likely to be helpful in establishing a diagnosis of ankylosing spondylitis?
A. C-reactive protein
B. Erythrocyte sedimentation rate
C. HLA typing
D. Serum alkaline phosphatase
E. Serum IgA
TheOne - 11-04-06 18:09
A 22-year-old male presents with complaints of dull lower back pain and morning stiffness. The pain was initially episodic, but now has become persistent and bilateral. On physical examination, there is tenderness over the costosternal junctions, spinous processes of the vertebrae, and the iliac crests. Which of the following tests would be most likely to be helpful in establishing a diagnosis of ankylosing spondylitis?
A. C-reactive protein
B. Erythrocyte sedimentation rate
C. HLA typing
D. Serum alkaline phosphatase
E. Serum IgA
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#2
Re: Pathology 27 Youngdoctor - 11-06-06 01:12 A 22-year-old male presents with complaints of dull lower back pain and morning stiffness. The pain was initially episodic, but now has become persistent and bilateral. On physical examination, there is tenderness over the costosternal junctions, spinous processes of the vertebrae, and the iliac crests. Which of the following tests would be most likely to be helpful in establishing a diagnosis of ankylosing spondylitis?
A. C-reactive protein
B. Erythrocyte sedimentation rate
C. HLA typing
D. Serum alkaline phosphatase
E. Serum IgA
Yes i agree totally HLA typing is most efficient and clear indication to do.Any more explanation.Please any one can put here.
#4
correct
TheOne - 11-06-06 11:13 Explanation: The correct answer is C. Ankylosing spondylitis is one of the spondyloarthropathies. It is a chronic inflammatory joint disease primarily affecting the vertebrae and the sacroiliac joints, usually beginning in late adolescence or early adulthood. Close to 90% of Caucasian patients with ankylosing spondylitis are HLA-B27 positive, so tests for this HLA type are the most helpful of those listed in establishing the diagnosis. C-reactive protein (choice A) and erythrocyte sedimentation rate (choice B) are non-specific markers of inflammation that can be elevated in active ankylosing spondylitis. Serum alkaline phosphatase (choice D) and serum IgA (choice E) can also be (usually mildly) elevated, but do not specifically suggest ankylosing spondylitis.
#5
Re: Pathology 27 galaxy - 05-28-10 02:09 Which of the following tests would be most likely to be helpful in establishing a diagnosis of ankylosing spondylitis?
C. HLA typing...HLA B27 is characteristic of ankylosing spondylitis..
#6
Re: Pathology 27 babbu5508 - 06-21-10 15:19 C. HLA typing HLA-B27 is strongly associated with a certain set of autoimmune diseases referred to as the "seronegative spondyloarthropathies".
#7
Re: Pathology 27 bingousmle - 06-30-10 22:07 I agree test that would be most likely to be helpful in establishing a diagnosis of ankylosing spondylitis is HLA typing...HLA B27 is characteristic of ankylosing spondylitis
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