USMLE Forum Archives - USMLE Step 1 - Pathology 29
Pathology 29
TheOne - 11-08-06 14:27
A 54-year-old man presents with complaints of shortness of breath, a sore tongue, and a pins-and-needles sensation in his feet. Laboratory examination reveals macrocytosis, anemia, and hypersegmented neutrophils. Antibodies to intrinsic factor are detected in the patient's serum. Which of the following class II antigens would be most likely to play a contributing role in the etiology of this patient's disease?
A. DR2
B. DR3
C. DR4
D. DR5
E. DR7
TheOne - 11-08-06 14:27
A 54-year-old man presents with complaints of shortness of breath, a sore tongue, and a pins-and-needles sensation in his feet. Laboratory examination reveals macrocytosis, anemia, and hypersegmented neutrophils. Antibodies to intrinsic factor are detected in the patient's serum. Which of the following class II antigens would be most likely to play a contributing role in the etiology of this patient's disease?
A. DR2
B. DR3
C. DR4
D. DR5
E. DR7
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#1
Re: Pathology 29
Kimo - 11-08-06 20:55 The answer to that question will be D. DR5 Pernicious anemia > B12 Deficiency, also Hashimoto's Thyroiditis.
good question
#2
Re: Pathology 29
TheOne - 11-21-06 16:13 Explanation: The correct answer is D. The disease with autoantibodies to intrinsic factor is pernicious anemia (atrophic gastritis and megaloblastic anemia secondary to vitamin B12 deficiency). Pernicious anemia is associated with the DR5 class II antigen (relative risk 5); DR5 is also associated with juvenile rheumatoid arthritis. DR2 (choice A) is associated with allergy, multiple sclerosis, and narcolepsy. DR3 (choice B) is associated with Goodpasture's syndrome, celiac sprue, Type 1 diabetes mellitus, and systemic lupus erythematosus. DR4 (choice C) is associated with pemphigus vulgaris, rheumatoid arthritis, and Type 1 diabetes mellitus. DR7 (choice E) is associated with steroid-responsive nephrotic syndrome.
#4
Re: Pathology 29 galaxy - 05-28-10 02:40 A 54-year-old man presents with complaints of shortness of breath, a sore tongue, and a pins-and-needles sensation in his feet. Laboratory examination reveals macrocytosis, anemia, and hypersegmented neutrophils. Antibodies to intrinsic factor are detected in the patient's serum. Which of the following class II antigens would be most likely to play a contributing role in the etiology of this patient's disease?
D. DR5
#5
Re: Pathology 29 babbu5508 - 06-21-10 15:46 D. DR5
DR5 is associated with persistent generalized lymphadenopathy and Kaposi sarcoma in AIDS, juvenile rheumatoid arthritis, pernicious anemia, Hashimoto's thyroiditis
#6
Re: Pathology 29 bingousmle - 06-30-10 21:41 .Pernicious anemia is associated with the DR5 class II antigen (relative risk 5); DR5 is also associated with juvenile rheumatoid arthritis.
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