USMLE Forum Archives - USMLE Step 1 - Pathology 30
Pathology 30
TheOne - 11-09-06 13:40
A 32-year-old medical technician had a history of acute eczematous dermatitis on her hands and wrist in the distribution of the latex gloves she wore. The skin of her hands was dry, crusted, and thickened. The eczematous reaction cleared after a 2-week vacation. After 72 hours back on the job, the eczematous dermatitis returned and continued to grow worse. Which of the following characterizes the technician's reaction to the latex gloves?
A. Irritant dermatitis
B. Type I reaction
C. Type II reaction
D. Type III reaction
E. Type IV reaction
TheOne - 11-09-06 13:40
A 32-year-old medical technician had a history of acute eczematous dermatitis on her hands and wrist in the distribution of the latex gloves she wore. The skin of her hands was dry, crusted, and thickened. The eczematous reaction cleared after a 2-week vacation. After 72 hours back on the job, the eczematous dermatitis returned and continued to grow worse. Which of the following characterizes the technician's reaction to the latex gloves?
A. Irritant dermatitis
B. Type I reaction
C. Type II reaction
D. Type III reaction
E. Type IV reaction
Page 1
#1
Re: Pathology 30
Kimo - 11-09-06 20:23 the Answer would be (E) Type IV hypersensitivity: Delayed (cell-mediated) type
Touching: Contact Dermatitis
let me know please if thats right
#2
Re: Pathology 30
TheOne - 11-21-06 16:02 Explanation: The correct answer is E. Sensitization to latex has become a major healthcare problem. Local skin irritations are common but more severe allergic reactions occur, up to and including rare anaphylactic reactions that are occasionally fatal. The immune responses to latex are immediate-type hypersensitivity (type I) reactions, expressing themselves in minutes, and/or delayed-type hypersensitivity (type IV) reactions, which will express themselves in 48-72 hours. The type I reactions are due to the IgE-mediated sensitivity to latex proteins while the type IV reactions are due to a cell-mediated response to the chemicals that are added in the processing of latex. The type IV response in this circumstance would be referred to as contact dermatitis. Irritant dermatitis (choice A) can be observed in the early stages of sensitization and can be due to sweating, rubbing, and residual soap. The timing of the reaction after 72 hours points to the type IV reaction rather than an irritant dermatitis. A type I reaction (choice B) would have been apparent in minutes with characteristic rhinitis, conjunctivitis, urticaria, asthma, angioedema, or anaphylaxis after she put on her latex gloves. A type II reaction (choice C) is a cytolytic response mediated by an antibody. The type II reaction is observed in the context of hemolytic anemias, thrombocytopenia, neutropenia, etc. A type III reaction (choice D) is an immune-complex response that sets into motion an inflammatory response.
#3
Re: Pathology 30 galaxy - 05-28-10 02:20 A 32-year-old medical technician had a history of acute eczematous dermatitis on her hands and wrist in the distribution of the latex gloves she wore. The skin of her hands was dry, crusted, and thickened. The eczematous reaction cleared after a 2-week vacation. After 72 hours back on the job, the eczematous dermatitis returned and continued to grow worse. Which of the following characterizes the technician's reaction to the latex gloves?
E. Type IV reaction...contact dermatitis type
#4
Re: Pathology 30 babbu5508 - 06-21-10 15:48 E. Type IV reaction.
skin reaction resulting from exposure to allergens (allergic contact dermatitis) or irritants (irritant contact dermatitis)
#5
Re: Pathology 30 bingousmle - 06-30-10 21:40 type IV reactions are due to a cell-mediated response to the chemicals that are added in the processing of latex lead to contact dermatitis
Page 1