USMLE Forum Archives - USMLE Step 1 - Pathology 32
Pathology 32
TheOne - 11-21-06 16:15
A 4-year-old child presents to a physician with purpura. Questioning of the mother reveals that the child also has a history of eczema and recurrent pneumococcal pneumonia. Blood studies demonstrate thrombocytopenia and a selective decrease in IgM. Patients with this disorder have a 12% chance of developing which of the following potentially fatal malignancies?
A. Astrocytoma
B. Chronic myelogenous leukemia
C. Colon carcinoma
D. Non-Hodgkin's lymphoma
E. Wilms' tumor
TheOne - 11-21-06 16:15
A 4-year-old child presents to a physician with purpura. Questioning of the mother reveals that the child also has a history of eczema and recurrent pneumococcal pneumonia. Blood studies demonstrate thrombocytopenia and a selective decrease in IgM. Patients with this disorder have a 12% chance of developing which of the following potentially fatal malignancies?
A. Astrocytoma
B. Chronic myelogenous leukemia
C. Colon carcinoma
D. Non-Hodgkin's lymphoma
E. Wilms' tumor
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#1
Re: Pathology 32 nrp - 11-22-06 06:15 D.The disease is Wiscott Aldrich syndrome.The patients are more prone to bone marrow suppression and lymphoma
#3
Re: Pathology 32 Youngdoctor - 11-24-06 17:48 A 4-year-old child presents to a physician with purpura. Questioning of the mother reveals that the child also has a history of eczema and recurrent pneumococcal pneumonia. Blood studies demonstrate thrombocytopenia and a selective decrease in IgM. Patients with this disorder have a 12% chance of developing which of the following potentially fatal malignancies?
A. Astrocytoma
B. Chronic myelogenous leukemia
C. Colon carcinoma
D. Non-Hodgkin's lymphoma
E. Wilms' tumor
It seems Non-Hodgkins lymphoma,But i am not quite sure about the explanation.Please i need a good explnation.
#4
Re: Pathology 32
TheOne - 11-26-06 13:27 Explanation: The correct answer is D. The patient has Wiskott-Aldrich syndrome, which is an X-linked partial combined immunodeficiency disorder. It presents clinically as the triad of thrombocytopenic purpura, eczema, and recurrent opportunistic infections with organisms having polysaccharide capsules, such as Streptococcus pneumoniae. The patients characteristically have decreased serum IgM and T-cell deficits (which appear later in life). Most patients die before the second decade of life, either from infection or from non-Hodgkin's lymphoma. Bone marrow transplantation has had some therapeutic success in these patients. None of the other neoplasms listed occurs with greater frequency in patients with Wiskott-Aldrich syndrome.
#5
Re: Pathology 32 galaxy - 05-28-10 02:20 A 4-year-old child presents to a physician with purpura. Questioning of the mother reveals that the child also has a history of eczema and recurrent pneumococcal pneumonia. Blood studies demonstrate thrombocytopenia and a selective decrease in IgM. Patients with this disorder have a 12% chance of developing which of the following potentially fatal malignancies?
D. Non-Hodgkin's lymphoma
#6
Re: Pathology 32 babbu5508 - 06-21-10 15:30 D. Non-Hodgkin's lymphoma...in wiskott aldrich syndrome it is common..there is thrombocytopenia, selective IgM deficiency,recurrent infections
#7
Re: Pathology 32 bingousmle - 06-30-10 22:05 triad of thrombocytopenic purpura, eczema, and recurrent opportunistic infections with organisms like strept points to Wiskott-Aldrich syndrome.. NHL
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