USMLE Forum Archives - USMLE Step 1 - Pathology 34
Pathology 34
TheOne - 11-21-06 16:18
A 21-year-old college student from Connecticut with a past history of Lyme disease presents with chronic pain and swelling in his right knee. He states that he has had problems with the knee for the past two years. Which of the following HLA alleles would you expect to be present in this individual?
A. HLA-B9
B. HLA-B17
C. HLA-B27
D. HLA-DR3
E. HLA-DR4
TheOne - 11-21-06 16:18
A 21-year-old college student from Connecticut with a past history of Lyme disease presents with chronic pain and swelling in his right knee. He states that he has had problems with the knee for the past two years. Which of the following HLA alleles would you expect to be present in this individual?
A. HLA-B9
B. HLA-B17
C. HLA-B27
D. HLA-DR3
E. HLA-DR4
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#2
Re: Pathology 34 Youngdoctor - 11-24-06 18:35 A 21-year-old college student from Connecticut with a past history of Lyme disease presents with chronic pain and swelling in his right knee. He states that he has had problems with the knee for the past two years. Which of the following HLA alleles would you expect to be present in this individual?
A. HLA-B9
B. HLA-B17
C. HLA-B27
D. HLA-DR3
E. HLA-DR4
Why do you think HLA-DR4 ?.I think HLA-DR3.Can you explain to me?.
#3
Re: Pathology 34
TheOne - 11-26-06 13:33 Explanation: The correct answer is E. Approximately 60% of patients in the United States who contract Lyme disease, but are not treated with antibiotics, will develop frank arthritis. The pattern typically consists of intermittent attacks of oligoarticular arthritis in large joints (especially knees) lasting for weeks to months in a given joint. Patients with persistent arthritis have a higher frequently of HLA-DR4 class II MHC complex than patients with brief Lyme arthritis or normal controls. HLA-B9 (choice A), and HLA-B17 (choice B) are not thought to be associated with Lyme disease arthritis. HLA-DR3 (choice D) is associated with a variety of disorders, but not Lyme disease arthritis. HLA-B27 (choice C), although associated with reactive arthritis, is not associated with Lyme disease arthritis.
#4
Re: Pathology 34 galaxy - 05-28-10 02:27 A 21-year-old college student from Connecticut with a past history of Lyme disease presents with chronic pain and swelling in his right knee. He states that he has had problems with the knee for the past two years. Which of the following HLA alleles would you expect to be present in this individual?
E. HLA-DR4
#5
Re: Pathology 34 babbu5508 - 06-21-10 15:33 HLA-DR4 association with lyme's arthritis is well known from long. The presence of HLA-DR4 in patients with arthritis was associated with a lack of response to antibiotic therapy
#6
Re: Pathology 34 bingousmle - 06-30-10 21:56 patients who will get Lyme disease if they are not treated with antibiotics, will develop single joint arthritis.HLA-DR4 is associated
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