Re: Pathology 38
nrp - 11-26-06 23:03

Is it mixed connective tissue disease?

Re: Pathology 38
v94527 - 11-26-06 23:55

..D

Re: Pathology 38
Jumana - 11-28-06 14:25

D indeed ;)

Re: Pathology 38
TheOne - 11-30-06 20:07

Explanation: The correct answer is D. Mixed connective tissue disease (MCTD) is clinically an overlap autoimmune disorder, including joint pain, myalgias, pleurisy, esophageal dysmotility, and skin disease. Interestingly, the condition is usually characterized by high antibody titers to ribonucleoprotein (RNP), which serves as a disease marker, and the condition is apparently immunologically distinct from other connective tissue disorders. Low titer RF and anti-ssDNA are common features of MCTD, but other autoantibodies are less commonly observed. Anti-centromere antibody is the distinctive marker for the CREST (choice A) variant of scleroderma, characterized by calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. Anti-SCI-70 is the distinctive marker for diffuse scleroderma (choice B), or systemic sclerosis, a multisystem disorder in which fibrosis of the skin, blood vessels, and viscera occurs. High titers of anti-histone antibody without other autoantibodies is the distinctive marker for drug-induced lupus (choice C). This disorder is particularly associated with administration of hydralazine and procainamide. High titers of anti-dsDNA is the distinctive marker for systemic lupus erythematosus (choice E).

Re: Pathology 38
galaxy - 05-28-10 02:32

Anti-ribonucleoprotein (anti-RNP) high titer
Rheumatoid factor (RF) low titer
Anti-single stranded DNA (anti-ssDNA) low titer
Anti-double-stranded DNA (anti-dsDNA) not detected
Anti-Smith antigen (anti-Sm) not detected
Anti-SCI-70 not detected

Which of the listed diseases is suggested by the antibody studies above?

D. Mixed connective tissue disease

Re: Pathology 38
babbu5508 - 06-21-10 15:37

D. Mixed connective tissue disease because Anti-ribonucleoprotein (anti-RNP) high titer,Rheumatoid factor (RF) low titer,Anti-single stranded DNA (anti-ssDNA) low titer

Re: Pathology 38
bingousmle - 06-30-10 21:52

Mixed connective tissue disease which is characterized by high antibody titers to ribonucleoprotein and has pain, myalgias, pleurisy etc

Re: Pathology 38
dinmenace - 06-30-11 23:41

d