USMLE Forum Archives - USMLE Step 1 - Ques. On Drug Interactions
Ques. On Drug Interactions
rarshad - 06-29-10 00:18
A patient aged 58 years who has had Coronary Angioplasty(Stent Insertion)is taking the following medicines:Clopidogrel,valsarten+Hydrochlorthaizide,rosuvastatin,aspirin.
Can he take CoenzymeQ10 (tablets)
rarshad - 06-29-10 00:18
A patient aged 58 years who has had Coronary Angioplasty(Stent Insertion)is taking the following medicines:Clopidogrel,valsarten+Hydrochlorthaizide,rosuvastatin,aspirin.
Can he take CoenzymeQ10 (tablets)
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Re: Ques. On Drug Interactions ktkmelody - 07-20-10 11:18 The bio-synthetic path way of Coenzyme Q 10 and cholesterols are common. Melovalonate, intermediate precursor of Coenzyme Q 10, is inhibited by Statins. So in this case use of rosuvastatin may reduce level of Coenzyme Q1o. However, Coenzyme Q 10 metabolized via Liver. Use of Aspirin may prolong half life as Aspirin is hepatic enzyme inhibitor. Subsequently, there is less metabolism of Coenzyme Q10. I think the benefit outweigh small risk. Anyone have any idea ?
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