USMLE Forum Archives - USMLE Step 1 - Sydenham's chorea
Sydenham's chorea
sshahraz - 08-02-08 11:26 Bookmark and Share

in this condition antibody is produced against neurons. which neuronal cells are the main target?

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#1
Re: Sydenham's chorea
bingousmle - 08-02-08 12:20

anti-basal ganglia antibodies detected by western immunoblot and immunofluoroscence. the condition is a autoimmune sequel to rheumatic fever, the Ab are targeted against streptococal aag crossreactwith the caudate and subthalamic nuclei

#2
Re: Sydenham's chorea
sshahraz - 08-02-08 19:14

exact answer. thanks!

#3
Re: Sydenham's chorea
mohhaider - 08-03-08 01:22

Good explanation bingousmle.

#4
Re: Sydenham's chorea
babbu5508 - 07-28-10 03:48

certain streptococcal proteins or antigens (streptococcal M proteins) induce the body's production of antibodies (i.e., antineuronal antibodies) that "crossreact" against the body's own cells in certain regions of the brain.

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